{"product_id":"melanotan-ii-pen","title":"Melanotan II | 30 mg pen","description":"\u003cp\u003e\u003cstrong\u003eMelanotan II\u003c\/strong\u003e is a peptide positioned for controlled research settings where \u003cstrong\u003emelanocortin receptor signaling\u003c\/strong\u003e is being studied in relation to \u003cstrong\u003emelanogenesis and pigmentation endpoints\u003c\/strong\u003e, \u003cstrong\u003ecentral appetite\/energy-balance readouts\u003c\/strong\u003e, and \u003cstrong\u003esexual arousal pathway activation\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupports\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eMelanocyte cAMP signaling and tyrosinase-linked melanogenesis (MC1R models)\u003c\/li\u003e\n\u003cli\u003ePigment distribution and eumelanin\/photoprotection endpoints in skin systems\u003c\/li\u003e\n\u003cli\u003eHypothalamic melanocortin tone in feeding-behavior paradigms (MC3R\/MC4R)\u003c\/li\u003e\n\u003cli\u003eLibido\/arousal pathway activation readouts in neuroendocrine models\u003c\/li\u003e\n\u003cli\u003eInflammation\/oxidative-stress signaling markers influenced by melanocortin pathways (model-dependent)\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch2\u003eDescription\u003c\/h2\u003e\n\u003cp\u003eMelanotan II is a synthetic analog of α-melanocyte-stimulating hormone (α-MSH) developed as a melanocortin receptor agonist for experimental research on pigmentation biology and neuroendocrine regulation. In controlled settings, it is commonly investigated for its ability to stimulate melanogenesis through melanocortin signaling in melanocytes and related pigment-cell models.\u003c\/p\u003e\n\u003cp\u003eBeyond peripheral pigmentation endpoints, Melanotan II is also studied for central melanocortin activity—particularly in pathways associated with appetite regulation and sexual arousal—where MC3R\/MC4R signaling is used as a mechanistic lens. Reported outcomes vary by model, receptor subtype involvement, and study design.\u003c\/p\u003e\n\u003cp\u003eMelanotan II is not positioned as a therapeutic agent on Peptoora and is presented for research context only, where receptor pharmacology, pigment outcomes, and behavioral endpoints can be evaluated under defined experimental controls.\u003c\/p\u003e\n\u003ch2\u003eClinical Status\u003c\/h2\u003e\n\u003cp\u003eMelanotan II has been evaluated in human studies focused on pigmentation outcomes and has also appeared in observational and case-based medical literature related to non-medical exposure. A substantial portion of mechanistic understanding is derived from animal and in vitro models characterizing melanocortin receptor signaling and downstream melanogenesis or neurobehavioral endpoints. It is not approved for therapeutic use.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEvidence type:\u003c\/strong\u003e\u003cbr\u003eHuman RCT ✔ | Observational ✔ | Animal ✔ | In vitro ✔ | Regulatory approval ☐\u003c\/p\u003e\n\u003ch2\u003eMechanism of Action\u003c\/h2\u003e\n\u003cp\u003eMelanotan II acts as an agonist across melanocortin receptor subtypes, with prominent research emphasis on MC1R-mediated melanocyte signaling. In melanocytes, MC1R activation is associated with increased intracellular cAMP, upregulation of melanogenic enzymes (including tyrosinase), and downstream increases in melanin production, supporting pigmentation and photoprotection research endpoints.\u003c\/p\u003e\n\u003cp\u003eCentral effects are commonly studied through MC3R\/MC4R signaling in hypothalamic circuits, where melanocortin tone is linked to feeding behavior, energy balance, and arousal-related pathways. Its cyclic peptide structure is often discussed as contributing to receptor affinity and in vivo stability relative to native α-MSH, although kinetics and receptor selectivity remain model- and assay-dependent.\u003c\/p\u003e\n\u003ch2\u003eBenefits\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eStimulation of Melanogenesis and Skin Pigmentation\u003c\/b\u003e:\u003cbr\u003eMelanotan II is a synthetic analog of\u003cspan\u003e \u003c\/span\u003e\u003cb\u003ealpha-melanocyte-stimulating hormone (α-MSH)\u003c\/b\u003e, studied for its ability to activate the\u003cspan\u003e \u003c\/span\u003e\u003cb\u003emelanocortin-1 receptor (MC1R)\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003ein melanocytes. This receptor activation increases melanin synthesis, resulting in a gradual darkening of skin tone. Research indicates enhanced UV protection through elevated eumelanin levels, supporting investigations into photoprotection and pigmentation modulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eEnhanced UV Protection and Skin Health\u003c\/b\u003e:\u003cbr\u003eBy promoting natural melanin production, Melanotan II enhances\u003cspan\u003e \u003c\/span\u003e\u003cb\u003ecellular defense against ultraviolet damage\u003c\/b\u003e. Studies demonstrate that increased melanin density helps absorb harmful UV radiation and reduce oxidative DNA damage in skin cells. This protective mechanism makes it a valuable subject in research related to skin photoprotection and anti-aging dermatology.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eAppetite and Energy Regulation Through MC4R Pathways\u003c\/b\u003e:\u003cbr\u003eMelanotan II also acts on the\u003cspan\u003e \u003c\/span\u003e\u003cb\u003emelanocortin-4 receptor (MC4R)\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003ewithin the hypothalamus, influencing appetite control and energy balance. Preclinical studies show reductions in caloric intake and fat accumulation, suggesting its role in experimental research on metabolic regulation, obesity, and neuroendocrine energy homeostasis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eImproved Libido and Sexual Function\u003c\/b\u003e:\u003cbr\u003eResearch on Melanotan II has demonstrated a strong influence on\u003cspan\u003e \u003c\/span\u003e\u003cb\u003esexual arousal and erectile function\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003ethrough central melanocortin receptor activation (particularly MC3R and MC4R). It stimulates pathways associated with libido and reproductive behavior in both male and female models, leading to its recognition as a subject of interest in sexual function research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNeuroprotective and Mood-Enhancing Effects\u003c\/b\u003e:\u003cbr\u003eStudies suggest that Melanotan II exerts\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eneuroprotective and mood-modulating actions\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003ethrough the melanocortin system’s influence on dopamine and serotonin pathways. This neuroendocrine activity may contribute to improved mood stability, motivation, and stress resilience, making it a focus of investigation in neuropeptide research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eReduction of Inflammation and Oxidative Stress\u003c\/b\u003e:\u003cbr\u003eMelanocortin activation by Melanotan II leads to suppression of\u003cspan\u003e \u003c\/span\u003e\u003cb\u003epro-inflammatory cytokines\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003esuch as TNF-α and IL-1β, along with enhanced antioxidant enzyme activity. These combined effects provide systemic anti-inflammatory protection, supporting research in inflammatory regulation, wound recovery, and cellular stress adaptation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePotential Support for Metabolic Optimization\u003c\/b\u003e:\u003cbr\u003eBy influencing hypothalamic signaling and lipid metabolism, Melanotan II may contribute to\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eincreased energy expenditure and improved insulin sensitivity\u003c\/b\u003e. This has led to growing research interest in its metabolic regulatory effects, particularly in models examining obesity, glucose tolerance, and lipid homeostasis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSynergy in Photoprotection and Skin Repair Research\u003c\/b\u003e:\u003cbr\u003eWhen combined with peptides such as\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eGHK-Cu or BPC-157\u003c\/b\u003e, Melanotan II enhances outcomes in experimental skin health and regenerative protocols. The synergistic stimulation of melanogenesis and collagen synthesis supports advanced studies in dermatological recovery and post-inflammatory hyperpigmentation control.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eLong-Lasting Pigmentation Maintenance\u003c\/b\u003e:\u003cbr\u003eMelanotan II provides\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eprolonged melanin retention\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eeven after cessation of administration, attributed to its stable receptor binding and extended activation of melanogenic pathways. This makes it ideal for research into long-term pigmentation stability and protective adaptation against environmental stressors.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eExploration in Neuroendocrine and Behavioral Pathways\u003c\/b\u003e:\u003cbr\u003eBeyond pigmentation and libido research, Melanotan II is studied for its\u003cspan\u003e \u003c\/span\u003e\u003cb\u003ecentral nervous system regulatory effects\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003evia the melanocortin network. Its influence on reward circuits, satiety, and emotional regulation suggests wider potential for understanding neuroendocrine integration and behavioral modulation mechanisms.\u003c\/li\u003e\n\u003cli\u003e\u003cbr\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eResearch Data\u003c\/h2\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse;\" cellpadding=\"10\" cellspacing=\"0\" border=\"1\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.2415%;\"\u003e\u003cstrong\u003eStudy\/model\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 64.7585%;\"\u003e\u003cstrong\u003eReported effect\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.2415%;\"\u003eHuman clinical trials (Phase 1-2)\u003c\/td\u003e\n\u003ctd style=\"width: 64.7585%;\"\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e↑ Skin pigmentation intensity and duration via increased melanin synthesis\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.2415%;\"\u003eHuman observational studies\u003c\/td\u003e\n\u003ctd style=\"width: 64.7585%;\"\u003e\n\u003cdiv\u003e\n\u003cdiv\u003eImproved erectile response and libido activation through MC4R signaling\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.2415%;\"\u003eRodent hypothalamic models\u003c\/td\u003e\n\u003ctd style=\"width: 64.7585%;\"\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e↓ Food intake and body weight via central melanocortin pathway modulation\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.2415%;\"\u003eIn vitro melanocyte cultures\u003c\/td\u003e\n\u003ctd style=\"width: 64.7585%;\"\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e↑ Tyrosinase activity and melanin production without UV exposure\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.2415%;\"\u003eRat metabolic studies\u003c\/td\u003e\n\u003ctd style=\"width: 64.7585%;\"\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e↑ Energy expenditure and lipid oxidation through MC3R\/MC4R activation\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.2415%;\"\u003ePharmacokinetic studies\u003c\/td\u003e\n\u003ctd style=\"width: 64.7585%;\"\u003e\n\u003cdiv\u003e\n\u003cdiv\u003eExtended plasma half-life and receptor binding stability vs α-MSH\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.2415%;\"\u003eBehavioral neurobiology models\u003c\/td\u003e\n\u003ctd style=\"width: 64.7585%;\"\u003e\n\u003cdiv\u003e\n\u003cdiv\u003eAltered dopaminergic response associated with mood and arousal\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eStack Suggestions\u003c\/h2\u003e\n\u003cp\u003eIn extended experimental designs, Melanotan II is sometimes paired with:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePT-141 (Bremelanotide) → to compare melanocortin-linked arousal signaling across different agonist profiles\u003c\/li\u003e\n\u003cli\u003eGHK-Cu → to co-study skin biology endpoints (matrix, repair signaling) alongside pigmentation readouts\u003c\/li\u003e\n\u003cli\u003eGlutathione (reduced) → to explore pigmentation\/oxidative-stress coupling in redox-focused skin models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eStacks discussed are for experimental design only, not safety\/efficacy guidance.\u003c\/p\u003e\n\u003ch2\u003ePossible Side Effects\u003c\/h2\u003e\n\u003cp\u003eMelanotan II may cause side effects, although these do not occur in all research subjects. Most common adverse reactions are transient and typically subside as the subject adapts to the compound. It is crucial to start with the lowest possible dose to gauge subject tolerance.\u003c\/p\u003e\n\u003cp\u003eNausea and Vomiting: This is the most frequently reported initial side effect, especially when higher doses are introduced rapidly. Nausea is often mild to moderate and tends to decrease over the first week of administration.\u003c\/p\u003e\n\u003cp\u003eFacial Flushing\/Warmth: Subjects may experience a temporary sensation of warmth and redness in the face or body shortly after injection. This is often linked to transient changes in blood pressure.\u003c\/p\u003e\n\u003cp\u003eAppetite Suppression: Consistent with the MC4R agonism, a noticeable reduction in appetite and food cravings is common, which may lead to weight loss over longer research cycles.\u003c\/p\u003e\n\u003cp\u003eHyperpigmentation of Moles\/Freckles: Existing moles or freckles may darken faster and become more pronounced than the surrounding skin. Researchers should document all dermatological changes carefully.\u003c\/p\u003e\n\u003cp\u003eInjection Site Reactions: As with any SubQ injection, minor redness, swelling, or irritation may occur at the injection site.\u003c\/p\u003e\n\u003cp\u003eSpontaneous Erections (Male Subjects): Due to the potent MC4R activity, male subjects may experience unexpected and prolonged erections during the initial research phase.\u003c\/p\u003e\n\u003cp\u003eIt is important to emphasize that most side effects of Melanotan II are dose-dependent, reversible, and manageable with careful dose titration.\u003c\/p\u003e\n\u003ch2\u003eScientific References\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8637402\/\"\u003eEvaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eHuman RCT\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34464955\/\"\u003eMelanotan II user experience: a qualitative study of online discussion\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eObservational\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23121206\/\"\u003eMelanotan II injection resulting in systemic toxicity and rhabdomyolysis\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eObservational\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7148395\/\"\u003eMelanotan II: a possible cause of renal infarction: review of the literature and case report\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eObservational\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4515169\/\"\u003eEvidence that melanocortin receptor agonist melanotan-II synergistically augments the ability of naltrexone to blunt binge-like ethanol intake in male C57BL\/6J mice\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eAnimal\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/dta.1655\"\u003eIdentification and characterization by LC-UV-MS\/MS of melanotan II skin-tanning products sold illegally on the internet\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eIn vitro\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7983590\/\"\u003ePreformulation studies with melanotan-II: a potential skin cancer chemopreventive peptide\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eIn vitro\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/jamanetwork.com\/journals\/jamadermatology\/fullarticle\/480676\"\u003eEffects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eHuman RCT\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/melanotan-ii\"\u003eMelanotan II – an overview\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eAnimal\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30142729\/\"\u003eA glimpse into the underground market of melanotan\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eObservational\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2050116120301859\"\u003eCase report melanotan tanning injection: a rare cause of priapism\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eObservational\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.actasdermo.org\/en-melanotan-articulo-resumen-S1578219012001382\"\u003eMelanotan | Actas dermo-sifiliográficas\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eIn vitro\u003c\/li\u003e\n\u003cli\u003e\u003cbr\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eCautions\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eFor educational and scientific context only; not intended to diagnose, treat, cure, or prevent any disease.\u003c\/li\u003e\n\u003cli\u003eIf you are pregnant, nursing, have a medical condition, or use prescription medication, consult a qualified professional.\u003c\/li\u003e\n\u003cli\u003eDiscontinue use if sensitivity occurs.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Peptoora","offers":[{"title":"30 mg","offer_id":61559774445898,"sku":"PE-BS-PEN-004","price":399.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0887\/1139\/7706\/files\/Melanotan_2_10mg.png?v=1775794104","url":"https:\/\/peptoora.com\/it\/products\/melanotan-ii-pen","provider":"Peptoora LTD","version":"1.0","type":"link"}